Speedball, powerball, or over and under[1] is the polydrug mixture of a stimulant with a depressant, usually an opioid. The most well-known mixture used for recreational drug use is that of cocaine and …

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Aug 27, 2025 · A speedball is a dangerous mix of a stimulant (most often cocaine) and a depressant (most often heroin or another opioid). This combination is especially risky because the opposing …

Mar 14, 2025 · A speedball is a combination of a stimulant (usually cocaine or methamphetamine) and a CNS depressant (typically an opioid), used simultaneously to produce an intense and dangerous high.

A speedball is a combination of heroin and cocaine that is usually injected, snorted or smoked. The high produced by the stimulant effect of cocaine combined with the depressant effect of heroin is …

Oct 19, 2025 · A speedball is a dangerous combination of a stimulant drug, such as cocaine, and a depressant drug, most commonly heroin. The two drugs have opposite effects on the body, which …

Sep 10, 2025 · A speedball is a combination of 2 strong and potentially lethal substances: heroin and cocaine. This deadly mix of uppers and downers is often prepared by mixing powdered cocaine, a …

Mar 22, 2025 · Speedball is a dangerous drug combination of cocaine and opioids. Learn what a speedball is, why it's so deadly, and its impact on the body.

Apr 18, 2025 · One of the most notorious forms of polydrug use is called “speedballing.” When someone engages in this type of substance use, they mix a stimulant drug with an opioid. For example, a …

Dec 2, 2025 · A “speedball” refers to combining two substances with opposing effects: a stimulant and a depressant. The classic mixture involves cocaine, a central nervous system (CNS) stimulant, and …