Some biological molecules with efficient noncovalent bonding sites can use their bonding properties to create well-defined assemblies from a single class of molecules–i.e., they assemble with each ...

Adeno-associated virus (AAV) mediates gene targeting in humans by providing exogenous DNA for allelic replacement through homologous recombination. In comparison to other methods of DNA delivery or ...

Recently it was shown that several new pseudotyped adeno-associated virus (AAV) vectors support cardioselective expression of transgenes. The molecular mechanisms underlying this propensity for ...

In patients with severe hemophilia B, gene therapy that is mediated by a novel self-complementary adeno-associated virus serotype 8 (AAV8) vector has been shown to raise factor IX levels for periods ...

Virus capsids can be formed through the self-complementary assembly of a single class of protein molecules. However, mimicking nature by making higher-ordered structures from artificial molecules has ...