The development of robust clinical trial methodologies increasingly relies on advanced statistical frameworks for model selection and the characterisation of dose–response relationships. With modern ...

Stylized curves that illustrate the linear, threshold, and hormetic dose-response models for carcinogens. The central pillar upon which toxicological assessments are built is the dose-response ...

A dose-response curve is the graphical representation of a dose-response relationship, the magnitude of response of an organism from exposure to drugs and chemical interactors. Usually, dose is ...

Lessons Learned From Implementing a Novel Bayesian Adaptive Dose-Finding Design in Advanced Pancreatic Cancer The trials can halt when a maximum tolerated dose (MTD) is estimated with sufficient ...

Objective To identify the optimal dose and type of physical activity to improve functional capacity and reduce adverse events in acutely hospitalised older adults. Design Systematic review and ...

Objective To estimate the dose–response associations between non-occupational physical activity and several chronic disease and mortality outcomes in the general adult population. Design Systematic ...

“For if one drinks much from a bottle marked ‘poison,’ it’s almost certain to disagree with one sooner or later.” —Lewis Carroll, “Alice’s Adventures in Wonderland” In the early 16th century, a Swiss ...

This is a preview. Log in through your library . Abstract The advantages of a generalised logistic dose response model as compared to a linear model were demonstrated while following the inhibitory ...

Harald Paganetti, Abdelkhalek Hammi and Clemens Grassberger (left to right) have modelled the dose to circulating blood during radiotherapy. (Courtesy: Abdelkhalek Hammi) “The blood flow model aims to ...